Paul D. Boyle, Ph.D.

1005 Brookside Dr. · Raleigh, NC 27604 · Phone: (919) 821-0522 · email: boyle@laue.chem.ncsu.edu

SKILLS

Physical Science

· X-ray Crystallography - Expert knowledge of X-ray crystallography and diffractometry, reciprocal lattice photography, accurate data collection and structure determination. Good understanding of computer controlled instrumentation. Able to do instrument maintenance and trouble shooting.

· Spectroscopic and Physical Characterization Experience - 31 P and 1 H NMR spectroscopy (routine and some experience with T 1 relaxation measurements), IR, UV-VIS, ESR, fast atom bombardment mass spectroscopy. Some experience with conductance measurements, magnetic susceptibility, cyclic voltammetry.

· Chemical synthesis - experienced in the synthesis and characterization of air sensitive compounds using Schlenk line techniques, and glove box.

Computing

· Programming - C, FORTRAN, c shell, shell programming, CGI application programming. Interfacing C code with legacy FORTRAN. General familiarity with UNIX systems programming, expecially termios and SYSV IPC interfaces, and POSIX.1 API. Exposure to BSD socket programming, tcl/tk, and C++.

· UNIX System Administration - well versed in installing, configuring, and administering Linux systems, experience with IRIX system administration. Custom configuration of kernel, managing users accounts, configuring basic network services including NFS and anonymous ftp, hardware installation, downloading, modifying, and installing software for local use. Creating backup schedules and scripts. Knowledge of X11 and use of networked graphics. Experience with PPP (client and server) configuration, Unix-Win95 interconnectivity with samba and Unix-Mac interconnectivity with netatalk. Website administration, including server configuration, implementation of restricted access areas, HTML authoring.

Teaching

· Able to provide individualized instruction on crystal mounting and instrument operations.

· Able to teach graduate level course in X-ray crystallography, including problem sets, exams, and computational exercises.

PROFESSIONAL EXPERIENCE

Co-Editor, Acta Crystallographica Section C

At North Carolina State University, Raleigh, NC 2000-present

· Responsible for review of scientific content of submitted manuscripts.

· Arrange for anonymous peer-review of submitted manuscripts.

Network Security Consultant

North Carolina State University, Raleigh, NC (supplemental 10% position) 1999-2001

· Prepared dual homed PC to act as an IP packet filtering firewall.

· Installed Linux (RedHat), recompiled custom kernel for routing and packet filtering functions

· Prepared shell script to invoke packet filtering rules, administer firewall

Director, X-ray Structural Facility

North Carolina State University, Raleigh, NC 1994-present

· Envisioned and implemented a complete modernization of the Facility, secured NSF equipment grant for acquisition of new instrumentation and computing facilities.

· Designed and implemented a well integrated computing environment for X-ray Facility using networked graphics (X11), networked printing facilities, dial up service using PPP, file sharing via NFS.

· Assisted NMR Facility Director in implementing an NFS environment (IRIX, Solaris, SunOS) for NMR Laboratory.

· Manage and direct daily operation of Facility, responsible for budget development and long range plans for the Facility.

· Determined structures by X-ray crystallography of inorganic complex, solid-state, organic, and organometallic samples.

· Designed and implemented an SQL based method of archiving and retieving crystal structure results using Relational Database Management System (RDBMS) software, including the development of Web aware database client software (written in UNIX C and PHP (an HTML embedded scripting language)). Interprocess Communication for client program was performed using SYSV IPC style message queues.

· Write software to interface crystallographic program packages, or to perform specialized calculations ( e.g. analysis of data from twinned crystals) using both FORTRAN and C.

· Performed bug fixes and submitted patches (FORTRAN) to Dr. Peter S. White for the NRCVAX crystallographic software package.

· Wrote a UNIX C program to debug serial port (termios) communication between Nonius CAD4 interface and diffractometer control software using pseudoterminals and SYSV IPC (shared memory, semaphores).

· Wrote "chi90s" and "hichi", C programs to find high c valued reflections given single crystal orientation matrix..

· Created easily upgradable NRCVAX package for Linux using the RedHat Package Management (RPM) software.

· Wrote CGI programs (C language) for quasi-interactive Web forms for the International Union of Crystallography World Directory of Crystallographers 10th ed. USA Section.

· Design and implement Facility networked automated back up schedules, Unix system administration (Linux and IRIX).

· Install, administer, and use computational chemistry packages (Cerius2 , Spartan, Gamess) on Facilty's Silicon Graphics.

· Perform computer hardware (including building PC's from parts) and software upgrades, porting software for local use.

· Set up and maintain a multiprotocol (ftp, NFS, http, samba, netatalk) "Results" server.

· Administer X-ray Facility Web server (URL http://laue.chem.ncsu.edu).

X-ray Crystallographer

University of New Brunswick, Fredericton, New Brunswick, Canada 1991-1994

· Managed daily operation of chemistry department Facility, responsible for budget and Facility planning.

· Determined molecular and crystal structures by X-ray crystallography of inorganic, organic, and organometallic samples.

· Assisted faculty and students in interpreting structural results.

· Wrote utility programs to convert output files for input into other programs, bond length correction program (FORTRAN).

· Wrote FORTRAN program to estimate rotation barriers from librational amplitudes following method of Dunitz & Maverick (see Mol. Phys. 1987, 62, 451-459).

· Performed conformational searches and energy minimizations with MacroModel 3.5 on small molecule structures.

· Performed computer hardware and software upgrades, ported software for local use.

· Supervised installation of departmental ethernet hardware.

· Administered Unix (Linux) systems.

Postdoctoral Fellow

Universität Bern, Bern, Switzerland 1988-1989

· Investigated dynamic pseudo Jahn-Teller distortion in crystals of [Cu(bipyam)2 (NO2)]NO 2 using multi-temperature X-ray diffraction data and compared results to the isomorphous Zn analog.

· Wrote FORTRAN progam to do simple simulations of disordered atom distributions.

Graduate Student and X-ray Laboratory Assistant

University of Minnesota, Minneapolis, MN 1983-1988

· Synthesized and characterized new mixed metal gold clusters polyhydride clusters from Au(I) precursors and Re polyhydrides. Characterization was done by 1 H and 31 P NMR, mass-spectroscopy, X-ray Crystallography, UV-VIS, conductance, ESR, IR.

· Determined X-ray crystal structures of inorganic, organometallic, organic, and bioinorganic model complexes, performed instrument maintenance.

Lando Fellow

University of Minnesota, Minneapolis, MN 1982

· Participated in research in synthesis and characterization of rhodium phosphine sulfhydryl complexes.

· Determined molecular structures by X-ray Crystallography.

Undergraduate Research Assistant

Syracuse University, Syracuse, NY 1980-1983

· Investigated C-H···O hydrogen bonding in Meldrum's Acid by X-ray crystallographic analysis using Weissenberg, precession, oscillation photography, powder diffraction, and single crystal diffractometry.

· Investigated solid-state thermal reactivity of bis(salicylaldiminato)copper(II).

EDUCATION

Postdoctoral Universität Bern, Bern Switzerland (Dr. Hans-Beat Bürgi) 1988-1989

Ph.D. University of Minnesota (Dr. Louis H. Pignolet) Chemistry, 1988

B.S. Syracuse University (Dr. Clarence E. Pfluger, Advisor) Chemistry, 1983

HONORS

Du Pont Fellow, University of Minnesota 1985-1986

Microelectronic & Information Sciences (MEIS) Fellow, University of Minnesota 1983-1984

Phi Beta Kappa, Syracuse University 1983

Charles Brubaker Berst Scholar, Syracuse University 1982-1983

Lando Summer Research Fellow, University of Minnesota 1982

Spenser Award Alpha Chi Sigma 1981

Paul D. Boyle

Appendix -- Publications & Presentations

PUBLICATIONS

Crystal and Molecular Structures of [RhCl(H)(m-SH)(PPh3) 2]·2.2CH 2Cl2 and [IrCl(H)(SH)CO(PPh3 )2]. Ann M. Mueting, Paul Boyle, and Louis H. Pignolet Inorg. Chem. 1984 , 23, 44.

Conformation and Intermolecular Interactions of Meldrum's Acid: An X-ray Structural Investigation of 2,2 Dimethyl-1,3-dioxane-4,6-dione. Clarence E. Pfluger and Paul D. Boyle J. Chem. Soc. Perkins Trans. II 1985, 1547.

Structures of Binuclear and Tetranuclear Iron(III) Complexes as Models for Ferritin Core Formation. Bruce P. Murch, Paul D. Boyle and Lawrence Que Jr. J. Am. Chem. Soc. 1985 , 107, 6728.

Mixed Metal Clusters. Synthesis and X-ray Structural Characterization of [Au5 Re(H)4 (PPh3) 7](PF6 )2 and [Au3Rh(H)(CO)(PPh 3)5 ](PF6). Paul D. Boyle, Brian J. Johnson, Angela Buehler, and Louis H. Pignolet Inorg. Chem. 1986, 25, 5.

Characterization of Large Cationic Transition Metal-Gold Clusters by Fast Atom Bombardment Mass Spectroscopy (FABMS). New Re-Au and Pt-Au Clusters: [Au4 Re(H)4 [P(p-tol)3] 2(PPh3 )4] +, [Au2 Re2(H) 6(PPh3 )6] + and [PtAu 6(PPh3 )7] 2+. Paul D. Boyle, Brian J. Johnson, Bruce D. Alexander, Joseph A. Casalnuovo, Patrick R. Gannon, Steven M. Johnson, Edmund A. Larka, Ann M. Mueting, and Louis H. Pignolet Inorg. Chem. 1987, 26, 1346.

Mixed Metal Gold Phosphine Clusters and their Reactivity towards Triphenylphosphine. Bruce D. Alexander, Paul D. Boyle, Brian J. Johnson, Joseph A. Casalnuovo, Steven M. Johnson, Ann M. Mueting, and Louis H. Pignolet Inorg. Chem. 1987, 26, 2547.

Heterobimetallic Au-Ir, Ag-Ir and Au-Ru Di-m-hydrido Complexes. X-ray Crystal and Molecular Structures of [AuRu(H) 2(dppm) 2(PPh3 )](PF6 ) and [Ir(H)2(bipy)(PPh 3)2 ]PF6. Bruce D. Alexander, Brian J. Johnson, Steven M. Johnson, Paul D. Boyle, Nina C. Kann, Ann M. Mueting, and Louis H. Pignolet. Inorg. Chem. 1987 , 26, 3506.

Iron-Oxo Aggregates. Crystal Structures and Solution Characterization of 2-Hydroxy-1,3-xylylenediaminetetraacetic Acid Complexes . Bruce P. Murch, Fontaine C. Bradley, Paul D. Boyle, Vasilios Papaefthymiou and Lawrence Que Jr. J. Am. Chem. Soc. 1987, 109, 7993.

Reaction of H 2S with [Ir(H)2 (Me2CO) 2(PPh3 )2]BF 4. Crystal and Molecular Structures of [Ir2(SH) 2(H)3 (PPh3) 4]BF4 ·2(CH3 )2CO, [Ir 2S(SH)(H) 3(PPh3 )4]·1.5C 6H6 , and [Ir2 (SH)(SC3H 7)(H)3 (PPh3) 4]BF4 ·(CH3 )2CO and Their Reactions with Organic Reagents. Ann M. Mueting, Paul D. Boyle, Robert Wagner, and Louis H. Pignolet. Inorg Chem. 1988, 27, 271.

Protonation of Transition Metal Acetates and Hydridoacetates with Fluorocarbon Acids. A. R. Siedle, R. A. Newmark, G. A. Korba, L. H. Pignolet, and Paul Boyle. Inorg. Chem. 1988 , 27, 1593.

Mixed Metal-Gold Clusters Compounds Containing Primarily Phosphine Ligands. Ann M. Mueting, Wim Bos, Bruce D. Alexander, Paul D. Boyle, Joseph A. Casalnuovo, Steven Balaban, Larry N. Ito, Steven M. Johnson, and Louis H. Pignolet. New Journal of Chemistry 1988, 12, 505.

Heterobimetallic Au-Os and Au-Ru Hydrido Complexes. X-ray Crystal and Molecular Structures of [Au 2Os(H)3 (PPh3) 5]PF6 and AuRu(H)2 (CO)(PPh3) 4]PF6 . Bruce D. Alexander, M. Pilar Gomez-Sal, Patrick R. Gannon, Christine A. Blaine, Paul D. Boyle, Ann M. Mueting, and Louis H. Pignolet. Inorg. Chem. 1988, 27, 3301.

Redox and Acid Base Chemistry of [Au 2Re2 (H)6(PPh 3)6 ]PF6 and Related Clusters. Paul D. Boyle, David C. Boyd, Ann M. Mueting, and Louis H. Pignolet. Inorg. Chem. 1988, 27, 4424.

The Preparation and Characterization of the Paramagnetic Solid Bis(1,2,3,4 trithiazolium)bis(hexafluoroarsenate) Containing the Dioxygen-like Dication Diradical ·+SSSNCCNSSS +· Paul D. Boyle, Simon Parsons, Jack Passmore, and Dale J. Wood J. Chem. Soc. Chem. Commun. 1993 , 199.

Organometallic Oxides: Reduction of (Pentamethylcyclopentadienyl)Niobium(V) and Tantalum(V) Oxo Complexes. Frank Bottomley, Paul D. Boyle, Selami Karslioglu, and Robert C. Thompson Organometallics 1993, 4090.

Organometallic Oxides: Convenient, High Yield Syntheses of the Pentamethypentadienylmolybdenum Oxo Complexes (h-C5Me 5)MoCl(O)2 , anti-[(h-C5 Me5)MoCl(O)] 2(m-O), and syn-[(h-C 5Me5 )Mo(O)(m-O)]2 . Frank Bottomley, Paul D. Boyle, and Jinhua Chen Organometallics 1994, 13, 370.

Unusual Weiss-Cook Condensation Dimethyl 2,3-Dioxobutanedioate and Dimethyl 3-Oxoglutarate. Ghislain Deslongchamps, Daniel Mink, Paul D. Boyle, and Nina Singh. Can. J. Chem. 1994, 72, 1162.

Preparations, X-ray Crystal Structures and FT-Raman Spectra of M3Cl 3AsF6 (M = S, Se) Containing the Novel Sulfur-Chlorine and Selenium-Chlorine Cations, ClS+ (Cl)SSCl and ClSe+ (Cl)SeSeCl. Pradip Bakshi, Paul D. Boyle, T. Stanley Cameron, Jack Passmore, Gabriele Schatte, and George W. Sutherland Inorg. Chem. 1994, 33, 3849.

Recent Advances in the Synthesis and Characterization of the O2-like paramagnetic solid SSSNC-CNSSS(M) 2 [M = AsF 6, Sb2 F11] Containing the Diradical ·+ SSSNC-CNSSS+· Paul D. Boyle, Jack Passmore, Dale J. Wood Phosphorus, Sulfur, and Silicon 1994, 93-94, 227.

Preparation and characterization of M3X3 AsF6 ( M = S, Se; X = Cl, Br). P. D. Boyle, T. S. Cameron, J. Passmore, G. Schatte, G. W. Sutherland J. Fluorine Chem. 1995, 71, 217.

Structural and EPR Studies of Vanadium Complexes of Deprotonated Amide Ligands: Effects on the 51V Hyperfine Coupling Constant. Charles R. Cornman, Edward P. Zovinka, Yvette D. Boyajian, Katherine M. Geiser-Bush, Paul D. Boyle, and Phirtu Singh Inorg. Chem. 1995, 34 , 4213.

The preparation and characterization of SeCl3 SbF6, improved syntheses of MCl3(As/Sb)F 6 (M = S, Se), and the X-ray crystal structure determination of SeCl3 AsF6 and a new phase of SBr3SbF 6. Jack Passmore, T. Stanley Cameron, Paul D. Boyle, Gabriele Schatte, and Todd Way Can J. Chem. 1996, 74, 1671.

Methyl Triphenylphosphoranylideneacetate: a Redetermination. Paul D. Boyle. Acta Cryst. C 1996, 2859.

The Synthesis and Characterization of New Neutral Metal Complexes Containing the Tetrathioethylene Unit Kimberly A. Proctor, Paul D. Boyle, and Robert D. Bereman J. Coord. Chem., 1996, 39, 43.

Methyl-Xanthines I. Anhydrous Theophylline. Yukiko Ebisuzaki, Paul D. Boyle, and Jennifer A. Smith Acta Cryst. C 1997, 777.

Oxidation of a Vanadium(V)-dithiolate Complex to a Vanadium(V)-h2 ,h2-disulfenate Complex. Charles R. Cornman, Thad C. Stauffer, and Paul D. Boyle J. Amer. Chem. Soc. 1997, 5986.

X-ray Crystal Structure of (CNSSS) 2(M)2 (M = AsF6- , SbF6- , Sb2F 11-) Paul D. Boyle, Stanley T. Cameron, Andreas Decken, Jack Passmore, Dale J. Wood Phosphorus, Sulfur, and Silicon, 1997, 124 & 125, 549.

Stabilization of the (p-indenyl)-Lead Bond: The First Structurally Authenticated Bis(h5 -indenyl) Complex of a Posttransition Element, [{1,3-(SiMe 3)2 }2Pb]. Jason S. Overby, Timothy P. Hanusa, and Paul D. Boyle Angew. Chem. Int. Ed. Engl. 1997, 36, 2378.

Structural and Electron Paramagnetic Resonance Studies of the Square Pyramidal to Trigonal Bipyramidal Distortion of Vanadyl Complexes Containing Sterically Crowded Schiff Base Ligands Charles R. Cornman, Katherine M. Geiser-Bush, Stephen P. Rowley, and Paul D. Boyle Inorg. Chem. 1997, 36, 6401.

Intramolecular Photocycloaddition of a Tethered Bis-2,3-dihydro-4-pyridone: Stereochemistry and Reactivity of the Cycloadduct Daniel L. Comins, Yong Sup Lee, and Paul D. Boyle Tetrahedron Letters 1998, 39, 187.

Structural studies of a borane modified phosphate diester linkage: Ab Initio Calculations on the Dimethylboranophosphate Anion, and the Single Crystal X-ray Structure of its Diisopropylammonium Salt Jack S. Summers, Diana Roe, Paul D. Boyle, Michael Colvin and Barbara Ramsay Shaw Inorg. Chem. 1998, 37, 4158.

The Synthesis and Characterization of Platinum Monodithiolene Complexes Containing 1,3-Dithiole-2-oxo-4,5-dithiolate (dmid2- ) and 1,3-Dithiole-2-thione-4,5-dithiolate (dmit 2-) Christopher E. Keefer, Suzanne T. Purrington, Robert D. Bereman, Brian W. Knight, Danny R. Bedgood and Paul D. Boyle Inorg. Chim. Acta. 1998, 282, 200.

Coordination Chemistry of a Tripodal S2ON Ligand: Syntheses, Structures and Reactivity of the MoVI and NiII Complexes of bis(2-mercaptoethyl)-2-amino-4-methylphenol (H3btap) and Comparision to VVO(btap) Charles R. Cornman, Kevin L. Jantzi, Jeseph I. Wirgau, Thad C. Stauffer, Jeff W. Kampf and Paul D. Boyle Inorg. Chem. 1998, 37 , 5851.

a- and b-CuAlCl 4: Framework Construction Using Corner Shared Tetrahedral Metal-Halide Building Blocks James D. Martin, Brian R. Leafblad, Roger M. Sullivan, and Paul D. Boyle Inorg. Chem. 1998 , 37, 1341.

Vanadium Compounds: Chemistry, Biochemistry, and Therapeutic Applications (ACS Symposium Series 711), Tracey, A. S.; Crans, D. C., Ed. 1998, Amer. Chem. Soc., Washington, D. C., pp 71-81.

Methyl Xanthines II. Anhydrous Theobromine Kimberly A. Ford, Yukiko Ebisuzaki, and Paul D. Boyle Acta Cryst. C , 1998, 1980.

Refined Synthesis of 5-Substituted Dipyrromethanes Benjamin J. Lettler, Mark A. Miller, Chen-Hsiung Hung, Richard W. Wagner, Donal F. O'Shea, Paul D. Boyle, and Jonathan S. Lindsey J. Org. Chem. 1999, 64, 1391.

The 195 Pt NMR of L2 Pt(1,2-dithiolenes) Christopher E. Keefer, Robert D. Bereman, Suzanne T. Purrington, Brain W. Knight and Paul D. Boyle Inorg. Chem. 1999, 38, 2294.

Hybrid organic-inorganic, hexa-arm dendrimers based on an Mo6 Cl8 core Gorman, C. B.; Su, W. Y.; Jiang, H. W.; Watson, C. M.; Boyle, P. Chem. Commun. 1999 877.

The Synthesis and Characterization of Metal Complexes of 4-(1',2'-Ethylenedithiolate)-1,3-dithiole-2-one (eddo2- ) and Dimeric Metal Complexes of 1,2,3,4-Butadienetetrathiolate (bdt4-). The Ligand Chemistry of 4,4'-bis(1,3-dithiole-2-one) (bdo) Christopher E. Keefer, Suzanne T. Purrington, Robert D. Bereman and Paul D. Boyle Inorg. Chim. Acta 1999, accepted for publication.

First Sytematic Synthesis of Heterobimetallic Dithiolene Bridged Complexes. Synthesis and Characterization of Metal Complexes of 4-(1',2'-Ethylenedithiolate)-1,3-dithiole-2-one (eddo 2-) and Dimeric Metal Complexes of 1,2,3,4-Butadienetetrathiolate (bdt4- ) Christopher E. Keefer, Suzanne T. Purington, Robert D. Bereman, Paul D. Boyle Inorg. Chem. 1999, 38, 5437.

Evidence for Spontaneous, Reversible Paracyclophane Formation. Aprotic Solution Structure of the Boron Neutron Capture Therapy Drug, L-p-Boronophenylalanine Brian K. Shull, David E. Spielvogel, Ramesh Gopalaswamy, Sabapathy Sankar, Paul D. Boyle, Gerald Head, and Kevin Devito J. Chem. Soc. Perkin Trans. 2, 2000, 557.

Zr6 Cl11-xI 2+xB (0 £ x £ 6): A Novel Mixed-Halide Structure Martin Köckerling; Johannes B. Willems; Paul D. Boyle Inorg. Chem., 2001, 40, 1439.

PAPERS & POSTERS PRESENTED

American Chemical Society National Meeting, New Orleans, Louisiana, September, 1987. The Use of Fast Atom Bombardment Mass Spectroscopy (FABMS) in Characterization of Cationic Polyhydride Metal Clusters. Paul D. Boyle, Brian J. Johnson, Bruce D. Alexander, Joseph A. Casalnuovo, Patrick R. Gannon, Steve M. Johnson, Edmund A. Larka, Ann M. Mueting, and Louis H. Pignolet.

University of Nijmegen, Nijmegen, Netherlands, August 1988, Invited Lecture. Rhenium-Gold Clusters. Paul D. Boyle,

American Crystallographic Association Annual Meeting, Albuquerque, New Mexico, May 1993. C-H···O Hydrogen Bonds in the Structure of a Highly Substituted Bicyclo[3.3.0]octene. Paul D. Boyle, Nina Singh, Daniel Mink, and Ghislain Deslongchamps.

International Union of Crystallography XVII Congress and General Assembly, Seattle, Washington, August 1996. Hydrogen Bonding and Conformational Analysis of a Novel Tetracyclic Fused Ring Molecule. Paul D. Boyle, Yong Sup Lee, and Daniel L. Comins.

American Crystallographic Association Annual Meeting, Arlington Virginia, July 1998. Using Relational Database Management Software to Archive and Retrieve Crystallographic Results. Paul D. Boyle, and C. Linus Hicks